Actually, there is a major deficiency worldwide in smoking prevention and cessation programs addressing women. Lung cancer is the most common cause of death from cancer worldwide; it is the third deaths cause in Europe after breast and prostate cancer. Lung cancer has different characteristics in women and in men; in women that smoke adenocarcinoma is more common. There is a difference in the behavior, prognosis and response to treatment in non-small cell lung cancer by sex and by hormonal status. Quitting smoking was associated with a reduction in mortality. Women are affected differently than men by tobacco consumption: the fear of weight gain is higher, smoking is practiced as an antidote to negative feelings or as a "time-out ", the socio-sensorial context has a greater impact on the addiction of women than nicotine, suggesting that the use of nicotine substitution therapy will have a low impact on this category of smokers. Women also give up smoking harder due to: a differentiated response to nicotine, lack of social support, depression and a specific hormonal configuration. More smoking relapses are described in women; also a differentiated correlation with tobacco exposure biomarkers ¹. That`s why there is a great need for a more personalized approach in this field, focused on the specific aspects of female tobacco consumption and cessation and on characteristics of lung cancer in females.