Introduction:
Long COVID is a recently described entity that is responsible for significant morbidity and that has consequences ranging from mild to life-threatening. Smoking has been reported as a risk factor for poor outcomes of acute SARS-COV-2 infection and seems to also play a role in promoting post-COVID-19 symptoms.

Aim:
To review the interaction between smoking and long-term COVID-19 in order to characterize smoking’s role as a risk factor and possibly identify new research directions.

Methods:
The PubMed/MEDLINE database was searched using the keywords ‘smoking’, ‘long COVID’, and ‘post-acute COVID’ to identify relevant English-language articles published up to December 2023.

Results and Conclusions:
From the 392 initial hits, a total of 37 papers were deemed relevant. There was significant variability concerning how tobacco usage was quantified and reported; still, there is compelling evidence linking smoking to an increased risk of developing various clinical manifestations of post-acute-COVID disorder. Some clinical conditions, such as dyspnea, cardiovascular symptoms, and cognitive or mental health impairment, seemed to be relatively strongly associated with tobacco use in COVID-19 patients. Data available firmly support recommending smoking cessation as a clinically valuable tool for avoiding long COVID-19 syndrome development.