In the past three decades, Romanian advocates and health professionals have participated to numerous educational programs dedicated to tobacco prevention and cessation in adults and training of experts in the field, but only recently Romanian researchers have involved in international tobacco control research projects. After a brief overview of educational programs with Romanian contribution ending with the EPACTT tobacco treatment guidelines still ongoing in many European countries, relevant as such research conducted in Romania will be presented here. The EQUIPT project (“European study on Quantifying Utility of Investment in Protection from Tobacco”) was a comparative effectiveness research aimed to provide policy makers with information about the economic and wider returns that investing in evidence-based tobacco control can generate; it involved Romanian input in its Research Advisory Group. The TOB G project (“Tobacco Cessation Guidelines for High-risk Groups”) developed and implemented an innovative and cost effective approach to treat tobacco dependence in adolescents, pregnancy and in smokers with diabetes, cardiovascular disease and COPD. Romanian team was responsible for personalized diabetes, cardiovascular and COPD group’s approach^{1, 2}. In the EUREST PLUS project (“European Regulatory Science on Tobacco: Policy Implementation to Reduce Lung Disease“), Romania acts to provide data on impact of the implementation of the Tobacco Products Directive across the EU.