Increasing tobacco prices is the most effective tobacco control intervention, but its effect may be attenuated by a presence of price differentials within and between countries. We compared price differences between median and cheapest cigarette prices across 79 countries worldwide for 2016, as well as differences in median prices of a variety of tobacco products, such as smokeless tobacco, cigars and roll-your-own tobacco. Price differentials for cigarettes were determined as the percentage of minimum over median price. Data were obtained from Euromonitor International, standardised to 20-cigarette packs or equivalent – for other tobacco products – based on nicotine content. Median pack-prices ranged between US$0.20 and US$16.20, and price differentials between 9.1% and 100%. Differences in median prices of various tobacco products varied widely across countries. Our findings highlight the large variation in price differentials between countries worldwide. Stricter tobacco taxation regulations should incorporate strategies to address price differentials, rather than solely rely on price increases in order to maximise the effect of taxation on tobacco use.