In recent years, it has become evident that low air quality in healthcare settings in the context of increased work pressure may be detrimental to healthcare personnel and patients. For instance, operating rooms, where the chemical burden and organic contaminators are frequently combined, are considered a case of low air quality index. In many studies, the quantification of the amount of Total Volatile Compounds (TVOCs), which were emitted from commonly used dental substances in a controlled dental micro-environment (surface disinfectants including both sprays and tissues, bonding agents, and acrylic substances), was assessed. Significant differences were observed between TVOCs emitted from sprays, which, in general, were substantially higher than TVOCs emitted from wipes (average TVOCs conc. from sprays 8.327 ppb, while the respective value for tissues is 496 ppb). An effort was made to assess the dependence of the measured TVOC concentrations on environmental factors such as wind speed and ventilation rates. It was found that the influence of environmental factors is not traceable, indicating the importance of emission patterns. When new technology of tissue removal is applied, and, more specifically, when using a laser on hard dental tissues, it was found that Er Yag laser activity is associated with high PM and TVOC concentration values. Many experiments resulted in a greater increase for PM2.5 than PM10, with all remaining above safety limits. This is an aspect professionals should consider, as severe health problems are attributed to fine particles. It was also found that TVOCs generated by the Er Yag laser's activity immediately exceeded and remained above safety limits values for more than 2 hours after the completion of the laser's workFinally when tobacco smoking is experienced indoors by healthcare personnel, even in auxiliary spaces the TVOCs are slightly increased. Still, the CO2, PM2.5, and PM 10 levels are extremely high, in short time intervals. In conclusion, in a heavily air-polluted environment, due to the hovering microdroplets and chemical pollution, as the dental offices are, it is necessary that any kind of smoking activity is prohibited, even when powerful air purifier apparatus or installations are available.