For decades, health professionals have actively promoted smoking cessation. Nicotine replacement therapy has proven its efficiency in treating the physiological aspect of the addiction but, to this day, it is still unclear what variables are involved in the treatment of the psychological and behavioral aspects of the addiction. For the past fifty years, therapeutical programs have been created but, due to the huge diversity of protocols, interventions and evaluations, it is still unclear what variables are in fact involved in the efficiency of a smoking cessation program. Therefore, the purpose of this communication is to show the main results based on a systematic analysis of the literature from the first smoking cessation programs in the 70’ to 2023. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method, 49 articles were included in the review with, overall, results showing a positive association between the personalization of a smoking cessation program and its efficiency. The results of this work highlight the importance for health professionals, when determining which intervention is best, to consider which smoker is faced in order to adapt the indication. When most of the existing programs offer one single form of intervention for all users, it appears necessary for future programs to offer a variety of interventions. And it is important, when evaluating the efficiency of a program, not only to observe the variables of the program itself, but also the characteristics of the users such as their sociodemographic profile as well as their motivational status and their smoking background. Therapeutical interventions in the field could benefit from a systematical review of those characteristics.