INTRODUCTION

Waterpipe tobacco smoking (WTS), a traditional tobacco use method that involves the heating of tobacco using charcoal and the inhalation of smoke after passing through water1, has been used in the Eastern Mediterranean Region for many centuries with evidence of growing popularity in recent years. A recent systematic review in 68 countries concluded that the prevalence of WTS is highest among adults in the Eastern Mediterranean (EM) Region, and among youth the prevalence was about equal between the EM and European regions2. Secondary analysis of the Global Youth Tobacco Survey reported that the highest prevalence rates in the EM region were in Lebanon (36.9%) and the West Bank of Palestine (32.7%) among students aged 13–15 years3. In Jordan, a study of university students (n=1845) reported 30% prevalence for past 30-day WTS4. In Egypt, 22.5% of university students reported to be waterpipe smokers5. A systematic review of waterpipe smoking prevalence among university students in Arab countries showed that males had significantly higher rates than females in most of the countries, the highest rates for males being in Egypt, Jordan and Palestine6. Several studies showed further gender differences among university students in Arab countries with relation to prevalence4, to perception of harm7, WTS initiation and smoking behavior8, females showing higher levels of perceived harm and lower levels of heavy smoking behaviors.

This increase in its popularity has been attributed to the introduction of sweet and aromatic tobacco flavors, increased social acceptability, especially among youth and women, the misperception that waterpipe is safer than cigarettes, and weaklyenforced waterpipe smoking control regulations9. Among youth, the spread of WTS is partly driven by the lack of awareness of the health risks associated with smoking1,10. One of the most effective population-based strategies to communicate the harms of smoking is the use of health warning labels (HWLs)11,12. A recent US study showed significant differences among participants based on their exposure to HWLs, with those not exposed having more puffs, reporting more satisfaction and reporting lower harm perception in WTS compared to those exposed to the HWLs13. HWLs have been evidenced to increase motivation to quit among university student smokers in the US14,15 and in Arab countries9,16,17. While these studies have showed various attitudinal responses to text and pictorial HWLs among university students who smoke waterpipe, no study has yet examined the differential responses to various HWLs including motivation to quit between male and female smokers in Arab countries. Analyzing gender differences by varying thematic warnings can help to better target appropriate gender specific interventions.

Although Article 11 of the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) has clearly recommended parties to adopt HWLs on all tobacco products, current WTS labels do not abide by the policies in terms of pictorial health warning, packaging, font warning size, and labelling of tobacco constituents18. Also, waterpipe HWLs are mostly present on tobacco packs, meaning that many users are rarely exposed to them19,20. In a qualitative study, adult smokers and non-smokers in Egypt stated that the placement of pictorial HWLs on the waterpipe device (as opposed to tobacco packs) would increase warning visibility, reduce intent for WTS initiation, and increase willingness to quit21. It was also suggested that pictorial HWLs should be placed on the waterpipe’s body, mouthpiece or hose21, however no study has yet determined the differential preference (if any) of the placement of the HWL on the waterpipe device by gender. Determining the optimal locations to place warning labels by target group could be valuable for future interventions and policy recommendations.

Café smokers are a particular group of smokers rarely exposed to HWL. In fact, figures have shown that 43% to 74% of young waterpipe users who smoke in cafés are not exposed to the HWLs22. This is of public health significance, given the increasing WTS café culture in the Eastern Mediterranean region, which is contributing to the social acceptability of waterpipe smoking. In Egypt, 64% of university students who are waterpipe smokers preferred smoking in a traditional café, 27% in a modern one (like restaurants), and only 2% preferred smoking waterpipe at home5. The slow pace and long sessions of WTS are conducive to social interactions among family and friends particularly within social gatherings in café settings23. Nakkash et al.22 reported in their qualitative study assessment that the availability of waterpipe in cafés and restaurants has contributed to a rise in WTS24, no study has yet examined the relationship between waterpipe smoking location (at the café vs at home), exposure to HWLs and motivation to quit.

Knowing that WTS is associated with multiple health risks, this study aims to explore the association between HWLs and the motivation to quit WTS among university students in three Eastern Mediterranean countries (Egypt, Jordan and Palestine), and to assess whether motivation to quit varies by type and message of the HWL, gender and by location of WTS (i.e. at home and café). We also investigate differences for the preferred location of the HWL on the waterpipe device among males and females in each of the three countries.

METHODS

Participants

This cross-sectional study was conducted in 2016 in three Eastern Mediterranean countries: Egypt, Jordan and Palestine. Data were collected from university students who were ever waterpipe smokers. Convenience sampling was used to recruit participants from university campuses using flyers and announcements via emails. Inclusion criteria were: 1) being between the ages of 18 and 29 years, 2) being a current university student, and 3) having smoked at least one or two puffs of waterpipe tobacco at least once, i.e. ever WTS. After obtaining consent, participants were provided access to the online survey, which was available in both English and Arabic. The study protocol was approved by the institutional review boards of all participating universities. No financial incentives were provided to participants. Additional details of the sampling and recruitment methods are available elsewhere.

Demographic characteristics and cigarette smoking

The questionnaire was adopted from previous research on waterpipe use among university students and assessed: demographics, attitudes towards waterpipe smoking, waterpipe smoking history and preferences, and reactions to HWLs25. Demographic characteristics included age (in years), gender (male or female), educational level (bachelor’s degree or less, enrolled in postgraduate degree program, or enrolled in a medical degree program), and employment status (employed or not employed). In addition to demographics, the survey assessed whether the participant smoked cigarettes in the past 30 days. Those who reported smoking on at least 1 day were categorized as current cigarettes smokers.

Waterpipe health warning labels

The HWL section consisted of nine text-only messages and four messages that included both text and pictorial imagery. Labels assessed were previously developed by Nakkash et al.18. Text-only HWLs included the following messages, each placed after the word ‘WARNING’: Waterpipe smoking is addictive (T1); Waterpipe smoke can harm children (T2); Waterpipe smoking causes fatal lung disease (T3); Waterpipe smoking causes cancer (T4); Waterpipe smoking causes strokes and heart disease (T5); Waterpipe smoking during pregnancy can harm the baby (T6); Waterpipe smoking can kill you (T7); Waterpipe smoke causes fatal lung disease in nonsmokers (T8); and Quitting waterpipe smoking now greatly reduces serious risks to your health (T9). Pictorial HWLs consisted of pictures coupled with one of the following messages: The water in waterpipe does not prevent toxic materials from reaching your body (P1); Waterpipe smoke contains a substance also found in rat poison (P2); Protect your children: Don’t let them be exposed to waterpipe smoke (P3); and Despite its pleasant smell, waterpipe smoke kills (P4) (Supplementary file, Figure 1). Current waterpipe users were asked if the text only and pictorial HWLs would motivate them to quit waterpipe smoking.

The actual response choices were: not at all, a little, a lot, and completely. These response items were collapsed into yes and no. Participants were also shown an image of options for HWL placement on the waterpipe device (i.e. device base, stem, hose, and mouthpiece; see Supplementary file, Figure 2) and asked where they think the HWL would be most noticeable.

Waterpipe tobacco smoking measures

Current waterpipe smoker was defined as any respondent who smoked waterpipe at least once in the past 30 days at the time of the survey. Participants were asked about the place where they usually smoke waterpipe tobacco (own home, someone else’s home, university accommodation, café/restaurant or other locations). We defined ‘At home only’ waterpipe tobacco smokers as any current waterpipe smoker who reported that they smoked waterpipe ‘in their own home’, ‘in someone else’s home’ or ‘university accommodations’ and responded as almost always/ always, usually/most of the time or often. We defined ‘in cafés only’ waterpipe tobacco smoker as those current waterpipe smokers who reported that they smoked waterpipe ‘in a café/restaurant’ almost always/ always, usually/most of the time or often. Those who responded to both were defined as smokers both at home and cafes whereas those who smoked in all other places were considered as smokers in ‘other locations’.

Statistical analysis

The analytic sample is a sub set of a broader sample of ever smokers. The analysis was conducted in each country to assess: 1) participants’ motivation to quit in response to textual health warning labels; 2) participants’ motivation to quit in response to pictorial health warning labels; and 3) the most noticeable location of a HWL on a waterpipe device by gender. In the descriptive analysis, means and standard deviations were calculated for continuous variables, and percent prevalence was reported for categorical variables. Chi-squared tests were done to determine the most noticeable location of a health warning label on a waterpipe device by gender. Additionally, multinomial logit regression models were used to determine the association of different variables with motivation to quit smoking in response to the health warning labels. Significant differences were reported at a p<0.05. All statistical analyses were performed using SPSS version 25.

RESULTS

The number of students who completed the survey was 728 in Egypt (72.5% males), 790 (62.9% males) in Jordan and 772 in Palestine (47.9% males). The mean age was 20.6 years (SD: 2.2), 21 years (SD: 2.2) and 23.8 years (SD: 2.8) in Palestine, Jordan and Egypt, respectively. Out of the total number of university students surveyed, the proportion of current waterpipe smokers was 73.8% in Egypt, 68.4% in Jordan and 63.2% in Palestine (Table 1).

Table 1

Characteristics of current waterpipe smokers by country

Palestine (n=487) n (%)Jordan (n=535) n (%)Egypt (n=442) n (%)
Age (years), mean ± SD20.6 ± 2.221.0 ± 2.223.8 ± 2.8
Gender
Female232 (47.6)189 (35.3)40 (9.1)
Male250 (51.3)345 (64.5)395 (89.4)
Education level
Bachelor’s degree or less427 (87.7)432 (80.8)312 (70.6)
Medical degree3 (0.6)82 (15.3)26 (5.9)
Postgraduate38 (7.8)15 (2.8)72 (16.3)
Employment status
Not employed286 (58.7)356 (66.5)147 (33.3)
Employed137 (28.1)139 (26.0)252 (57.0)
Past 30-day cigarette smoking
No307 (63.0)318 (59.4)183 (41.4)
Yes161 (33.1)209 (39.1)230 (52.0)

Placement of health warning label

In all three countries, current waterpipe smokers reported that the most noticeable location of a HWL on a waterpipe device is the mouthpiece (Table 2). The proportion of female university students who chose the mouthpiece was higher compared to males in all countries. Among female current waterpipe smokers, 60.3% in Palestine, 58.0% in Jordan and 54.1% in Egypt selected the mouthpiece as the most noticeable location for a HWL; whereas among male current users, 54.1% in Palestine, 52.9% in Jordan and 45.6% in Egypt selected it. The mouthpiece was followed in ranking by the stem, the base and the hose across countries and genders, except for Palestine, where male current users preferred the base (24.4%) over the stem (19.4%). In all countries and for both genders, the hose was considered the location where the HWL can be least noticed (Table 2).

Table 2

Reported most noticeable health warning label location among current waterpipe smokers by gender

PalestineJordanEgypt
Total (n=487)Female (n=232)Male (n=250)pTotal (n=535)Female (n=189)Male (n=345)pTotal (n=442)Female (n=40)Male (n=395)p
n (%)n (%)n (%)0.364n (%)n (%)n (%)0.450n (%)n (%)n (%)0.796
Base100 (21.2)41 (17.9)59 (24.4)81 (15.9)28 (15.5)53 (16.1)60 (14.1)4 (10.8)56 (14.4)
Mouthpiece269 (57.1)138 (60.3)131 (54.1)279 (54.7)105 (58.0)174 (52.9)198 (46.4)20 (54.1)178 (45.6)
Stem93 (19.7)46 (20.1)47 (19.4)129 (25.3)39 (21.6)90 (27.4)143 (33.5)11 (29.7)132 (33.9)
Hose9 (1.9)4 (1.8)5 (2.1)21 (4.1)9 (5.0)12 (3.7)26 (6.1)2 (5.4)24 (6.2)

Motivation to quit (pictorial warnings)

In all countries, the HWL P3 ‘Protect your children: Don't let them be exposed to waterpipe smoke’ was more likely to motivate current waterpipe smokers to quit while the label P1 ‘The water in waterpipe does not prevent toxic materials from reaching your body’ was the least effective (data not shown).When studying the association of gender with motivation to quit in response to pictorial health warning labels, no significant differences were seen among males and females in all countries (Table 3). As for the smoking location, the label that mostly motivated participants to quit smoking in all smoking locations was the one asking smokers to protect their children, with respondents in Egypt showing the highest endorsement (71.9%) (data not shown). When studying the association of smoking location with motivation to quit, home-only smokers in Palestine were 2 times more motivated to quit than home and café smokers when seeing the pictorial warning label ‘The water in waterpipe does not prevent toxic materials from reaching your body’ P1: 2 (95% CI: 1.1–3.3) and when seeing the warning ‘Protect your children: Don't let them be exposed to waterpipe smoke’ P3: 1.9 (95% CI: 1.2–3.2), controlling for age, gender, education level, employment status, and past 30-day cigarette use. These results were not detected in Jordan nor in Egypt. Smokers who smoke in other locations seem to have the highest motivation to quit as response to all 4 pictorial HWL in both Palestine and Jordan, whereas this was not observed in Egypt.

Table 3

Association of different variables with motivation to quit in response to pictorial health warning labels using multinomial logit regression model

VariablePalestineJordanEgypt
P2P2P3P4P1P2P3P4P1P2P3P4
Age (≥21 years)1.3 (0.8–2.0)1.0 (0.7–1.6)1.0 (0.7–1.5)0.8 (0.5–1.2)1.0 (0.7–1.4)0.8 (0.6–1.2)1.1 (0.7–1.6)1.0 (0.7–1.4)1.0 (0.6–1.7)0.7 (0.4–1.2)1.0 (0.5–1.8)0.8 (0.5–1.3)
Gender (female)0.9 (0.6–1.4)1.4 (0.9–2.1)1.3 (0.9–2.0)0.9 (0.6–1.4)1.1 (0.8–1.6)1.2 (0.8–1.8)1.3 (0.9–1.9)1.3 (0.9–1.9)0.8 (0.4–1.6)1.0 (0.5–2.0)1.0 (0.4–2.2)1.2 (0.6–2.6)
Education (postgraduate)1.1 (0.5–2.4)1.0 (0.5–2.1)1.2 (0.6–2.6)1.7 (0.8–3.6)1.3 (0.8–2.1)1.7* (1.1–2.7)1.6* (1.0–2.6)1.1 (0.7–1.8)1.4 (0.8–2.6) 1.21.2 (0.7–2.1)1.3 (0.7–2.6)1.6 (0.9–3.0)
Working status (not employed)1.3 (0.8–2.2)1.2 (0.7–1.8)1.3 (0.8–2.0)1.0 (0.6–1.6)0.7 (0.5–1.1)0.9 (0.6–1.3)1.0 (0.6–1.4)0.8 (0.6–1.2)0.5* (0.3–0.8)0.4* (0.3–0.7)0.3* (0.2–0.6)0.4* (0.2–0.7)
Smoked cigarettes in past 30 days0.9 (0.5–1.4)0.9 (0.6–1.4)0.7 (0.5–1.1)0.6* (0.4–1.0)0.8 (0.5–1.1)0.9 (0.6–1.3)0.9 (0.6–1.3)1.0 (0.7–1.4)0.3* (0.2–0.5)0.3* (0.2–0.5)0.5* (0.3–0.9)0.2* (0.1–0.4)
Smoking location (café and home)
Café only1.2 (0.7–2.1)1.5 (0.9–2.5)1.7 (1–2.7)1.4 (0.8–2.4)1.1 (0.7–1.6)1.5 (1.0–2.3)1.1 (0.8–1.8)1.4 (0.9–2.3)0.8 (0.5–1.4)0.8 (0.5–1.4)1.0 (0.5–1.8)0.9 (0.5–1.5)
Home only2* (1.1–3.3)1.3 (0.8–2.2)1.9* (1.2–3.2)1.5 (0.9–2.5)0.7 (0.5–1.1)1.4 (0.9–2.2)1.4 (0.9–2.2)1.3 (0.9–2.1)-1.2 (0.2–7.0)0.8 (0.1–4.5)0.7 (0.2–3.5)
Other locations3.5* (2.0–6.2)3.3* (1.9–5.7)3.1* (1.7–5.6)3.4* (1.9–6.0)2.6* (1.5–4.5)3.3* (1.9–5.8)3.8* (2.0–7.3)4.3* (2.5–7.7)1.0 (0.1–11.9)---

* p<0.05.

P1: The water in waterpipe does not prevent toxic materials from reaching your body. P2: Waterpipe smoke contains a substance also found in rat poison. P3: Protect your children, don’t let them be exposed to waterpipe smoke. P4: Despite its pleasant smell, waterpipe smoke kills. Participants making a negative response to the warning label were the reference category. In the smoking location, both café and home smokers were considered as a reference category.

Motivation to quit (text warnings)

Table 4 shows participants’ motivation to quit in response to text-only HWLs. Not all textual warning labels are reported in this table as some of them did not show significance. In Palestine, female smokers were 1.8 times (95% CI: 1.1–2.8) more motivated to quit waterpipe smoking when seeing the textual warning label T2: ‘waterpipe smoke can harm children’ and 2.7 times (95% CI: 1.6–4.3) more motivated to quit when seeing the warning label T6: ‘waterpipe smoking during pregnancy can harm the baby’ compared to males. Similar results were found in Jordan [T2: 1.6 (95% CI: 1.0–2.6); T6: 1.8 (95% CI: 1.1–3.0)]. In Egypt, the warning label related to pregnancy showed less motivation to quit in females than males T6: 0.3 (95% CI: 0.1–0.7). As for the smoking location, smokers who smoke at home only in Palestine were 2 times more likely to consider waterpipe smoking as addictive T1: 2.3 (95% CI: 1.4–3.7), harmful for children T2: 2.3 (95% CI: 1.4–4.1), harmful for the baby during pregnancy T6: 2.4 (95% CI: 1.3–4.3), and to believe that quitting reduces the health risks T9: 1.8 (95% CI: 1.0–3.1). Similarly, café only smokers were also more motivated to quit (1.9 to 2.9 times) as a response to T2, T6, and T9. In contrast, café only smokers in Egypt were 2.5 to 3.3 times less likely to respond to the HWL T1 and T9 [T1: 0.4 (95% CI: 0.2–0.7 and T9: 0.3 (95% CI 0.2–0.7)]. Smokers who smoke in other locations (such as at a friend’s house, etc.) seem to have the highest motivation to quit as response to all 4 textual HWL in both Palestine and Jordan, whereas this was not observed in Egypt.

Table 4

Association of different variables with motivation to quit in response to textual health warning labels using multinomial logit regression model

VariablePalestineJordanEgypt
T1T2T6T9T1T2T6T9T1T2T6T9
Age (≥21 years)0.8 (0.5–1.2)0.9 (0.5–1.4)0.8 (0.5–1.3)0.6* (0.4–1.0)1.1 (0.8–1.6)1.1 (0.7–1.7)1.0 (0.6–1.6)1.3 (0.8–2.1)0.9 (0.5–1.5)0.9 (0.4–1.8)0.7 (0.3–1.6)0.9 (0.5–1.8)
Gender (female)1.1 (0.7–1.6)1.8* (1.1–2.8)2.7* (1.6–4.3)1.4 (0.9–2.1)1.3 (1.0–1.9)1.6* (1.0–2.6)1.8* (1.1–3.0)1.1 (0.7–1.9)1.2 (0.5–2.5)0.5 (0.2–1.2)0.3* (0.1–0.7)1.1 (0.4–2.9)
Education (postgraduate)0.9 (0.4–1.8)1.1 (0.5–2.6)0.8 (0.3–1.8)0.8 (0.4–1.7)1.0 (0.6–1.6)0.8 (0.5–1.4)0.7 (0.4–1.2)0.6 (0.4–1.1)1.3 (0.7–2.3)1.0 (0.4–2.3)1.3 (0.5–3.0)1.3 (0.6–2.8)
Working status (not employed)1.0 (0.6–1.5)1.6 (1.0–2.6)1.5 (0.9–2.6)1.4 (0.9–2.3)0.8 (0.5–1.2)0.7 (0.4–1.2)0.8 (0.5–1.4)1.4 (0.9–2.3)0.3* (0.2–0.5)0.4* (0.2–0.8)0.4* (0.2–0.9)0.5 (0.3–1.0)
Smoked cigarettes in past 30 days0.5* (0.4–0.8)1.0 (0.6–1.5)0.9 (0.5–1.4)0.6* (0.4–1.0)0.9 (0.6–1.2)1.2 (0.7–1.8)0.9 (0.6–1.4)1.0 (0.6–1.6)0.2* (0.1–0.4)0.5 (0.3–1.0)0.4* (0.2–0.9)0.1* (0.0–0.3)
Smoking location (café and home)
Café only1.5 (0.9–2.5)2.5* (1.4–4.4)2.9* (1.6–5.4)1.9* (1.1–3.3)1.4 (0.9–2.2)1.6 (0.9–2.8)1.7 (1.0–3.1)1.9* (1.1–3.3)0.4* (0.2–0.7)1.0 (0.4–2.1)0.6 (0.2–1.4)0.3* (0.2–0.7)
Home only2.3* (1.4–3.7)2.3* (1.4–4.1)2.4* (1.3–4.3)1.8* (1.0–3.1)1.1 (0.7–1.7)1.1 (0.6–1.8)0.9 (0.5–1.5)1.2 (0.7–2.1)0.6 (0.0–7.3)
Other locations3.9* (2.2–7.1)3.4* (1.7–6.7)3.1* (1.6–6.4)2.1* (1.1–4.1)3.0* (1.7–5.4)2.0 (0.9–4.2)1.8 (0.8–4.0)3.7* (1.5–9.2)0.6 (0.0–8.7)

* p<0.05.

T1: Waterpipe smoking is addictive. T2: Waterpipe smoke can harm children. T3: Waterpipe smoking causes fatal lung disease. T4: Waterpipe smoking causes cancer. T5: Waterpipe smoking causes strokes and heart disease. T6: Waterpipe smoking during pregnancy can harm the baby. T7: Waterpipe smoking can kill you. T8: Waterpipe smoke causes fatal lung disease in non-smokers. T9: Quitting waterpipe smoking now greatly reduces serious risks to your health. Only T1, T2, T6 and T9 are presented here because the other warning labels did not show significance. Participants making a negative response to the warning label were the reference category. In the smoking location, both café and home smokers were considered as a reference category.

DISCUSSION

The prevalence of waterpipe smoking among youth in the Eastern Mediterranean Region has risen as waterpipe is perceived as less harmful compared to other tobacco products1. Since HWLs have been proven effective in conveying the health risks of smoking to the public13,14, we report on the effect of these labels on motivation to quit waterpipe smoking among university students in the Eastern Mediterranean Region by gender and smoking location. Health warnings communicating the harm of waterpipe smoke to children and fetuses during pregnancy were the most effective at motivating current smokers to quit. This finding is consistent with other research conducted in the region16,26,27 as well as in the United States14. This might suggest that individuals who are of reproductive age are more concerned about the possible risks of waterpipe smoking to children, infants and childbearing women28, and these attitudes can be observed among young people across different countries and cultures. Similar effects of warnings related to child health have been observed among cigarette smokers29. These findings are in accordance with a recent international expert panel consensus, where labels related to waterpipe’s harmful effects on newborn children were identified as being among the most effective at communicating WTS-related risks30. Furthermore, our results show that the motivation to quit in response to text warning labels was significantly higher among females than males for text warnings related to harm to children or during pregnancy. Similar genderspecific findings can be found in studies evaluating the effect of HWLs related to pregnancy and child health on WTS31 as well as on cigarette smoking29,32. These findings confirm the need for gender-specific considerations in the design of interventions and policies to reduce tobacco smoking and/or increase the motivation to quit.

The theory of planned behavior33 and the extended parallel process model15 have been suggested to inform the investigation of factors affecting WTS behavior and intention to quit, although these theories had not been previously applied to assess the effect of waterpipe HWLs on intention to quit. In extrapolation, such theorybased studies have been conducted to address HWLs in cigarette smoking. Using the extended parallel process model, motivation to quit cigarette smoking was targeted by emphasizing the need for messaging that ‘should contain both threat and efficacy messages to increase risk perceptions and efficacy beliefs’28. Health warnings communicating the negative consequences of WTS to others such as harm to fetuses, infants and children were found to increase respondents’ motivation to quit. These findings may reflect a general moral need to protect the health of children who may be perceived as vulnerable, suggesting that perceived severity and negative emotional reactions such as concern for others may be primary factors contributing to intention to quit28. More theory-driven research should be conducted to understand the factors affecting attitudinal and behavioral responses to waterpipe HWLs.

The social dimension of WTS as well as the emergence of café culture in Eastern Mediterranean countries have contributed to the increased popularity of WTS among youth1. Although previous studies have shown how HWLs focusing on harm to self and to others motivated youth to quit WTS9,16, no study has yet assessed motivation to quit by pattern of usual or preferred smoking location. In our study, we found that home-only smokers and café-only smokers can be motivated to quit in response to text warning labels related to health (i.e. harm to self) and labels related to pregnancy and children (i.e. harm to others), whereas pictorial warnings do not seem to differentially affect café-only smokers. We also observed a negative or opposite reaction in Egypt, where café-only smokers consistently showed lowest motivation to quit in response to both pictorial and text HWLs. This may be partly due to the difference in cultural background, the social acceptability and the social norms associated with smoking which affect to a large extent the motivation to quit waterpipe smoking. In Egypt, the majority of university students prefer to smoke at a café or local restaurant5. Café customers were considered as established smokers in a study conducted in Syria, and established smokers showed less willingness to quit34. This has intervention and policy implications, highlighting the need to address the social dimension of waterpipe smoking, in addition to targeted awareness with health warning labels. It is also worth noting that compared to both home and café smokers, smoking in ‘other location’ was associated with a higher motivation to quit in response to almost all the warning labels. Further exploratory research is needed to identify these locations (which could be any informal setting such as park, beach etc.) in order to develop suitable tobacco regulations.

Irrespective of the compliance of the waterpipe HWL with the FCTC recommendations on the tobacco pack, the lack of exposure to the tobacco pack in café settings means that a considerable proportion of the targeted population is not reached. In line with other studies9,20,21, we found that placing the HWL on the mouthpiece would make it most noticeable for both males and females. While a prior study suggested that this location would be the most effective for non-users16, our study suggests that placing a health warning on the mouthpiece is also effective for current waterpipe smokers. These variations emphasize the importance of targeted interventions and policies in café settings and those targeting café-only smokers. Our study also confirms previous policy recommendations related to placing the targeted HWL on the waterpipe device, especially the mouthpiece14,20,21.

Strengths and limitations

To our knowledge, this study is the first to evaluate motivation to quit waterpipe smoking in response to HWLs by gender and smoking location, thus, setting the stage for future studies among WTS in other regions. The sample size was sufficiently large giving the study sufficient power to detect significant differences between the groups being studied. Limitations include the possibility of response bias due to self-reporting as well as generalizability constraints due to the use of convenience sampling and the fact that the sample included only university students who may not be representative of the entire young adult population. Another limitation is that the survey did not include questions on nicotine addiction, frequency of smoking, years of smoking, which are variables that may have also impacted the motivation to quit in response to the exposure to the HWLs.

CONCLUSIONS

Our findings have implications on waterpipe smoking research, practice and policy. Health warning themes related to pregnancy and children’s health were the most effective at motivating young adults to quit waterpipe smoking in all three countries with females being significantly more motivated than males in Palestine. This suggests the need for gender-specific and gender-targeted messaging and interventions when addressing intention to quit waterpipe smoking, as well as more investment in gender and feminist research to understand gender-specific variations in waterpipe smoking behaviors. Also, more theorydriven research would help elucidate the underlying factors associated with increased motivation to quit in response to HWLs. Variations in responses to HWLs by usual or preferred smoking location brings implications in the design and delivery of targeted interventions as well as regulatory policy recommendations, which need to address café and athome smoking setting patterns, as well as placement of HWLs on the waterpipe device.