There is currently a lack of up-to-date representative data for Poland on the use of nicotine products, in particular novel nicotine products. The study’s main objective is to assess the use of nicotine products, including new nicotine-containing products, and to identify health-related risk factors in the Polish population. It is planned that a mixed methods study will be conducted using qualitative methods in the form of individual in-depth interviews (IDI) and quantitative methods in the form of an epidemiological, cross-sectional, questionnaire-based survey. In phase one, IDI will be conducted. A total of 100 respondents from 5 different groups of users of nicotine products will be interviewed: minors aged 12-17, young adults aged 18-25, the LGBT community, pregnant and post-partum women, and young health professionals. A survey questionnaire will be prepared based on the IDI results obtained and the tools used in the PATH study. In the second stage, a pilot questionnaire survey will be carried out on 1,000 people. Based on the results obtained, the questionnaire will be validated. In the third stage, a nationwide representative cross-sectional survey will be conducted on 9,000 people. A random sample of Polish residents will be recruited among men and women aged 12-65, both using and not using nicotine products. The survey is expected to provide information on the prevalence of nicotine product use and differences in attitudes, behaviors, and health perceptions regarding nicotine use in the Polish population. The results obtained will provide valuable data for the development of health policies, including the implementation of age restrictions, regulations on the sale and advertising of new nicotine products, and the preparation of public health interventions that could reduce the long-term impact of nicotine use and the associated social and economic costs.