Introduction:
The aim of the study was the identification the relationship of clinical characteristics indicating unfavorable course of tobacco addiction in individuals with drug resistance, with a variation (polymorphism) of the gene nicotinic receptor rs578776 and COMT gene rs4680.

Material and Methods:
Clinical and psychopathological study was conducted in 53 patients with tobacco dependence of high level (Fagerstroem). All patients were divided into 2 groups - primary (n=29, age 48,5±2,5 years) with a history of pharmacological resistance (to Varenicline, Nicorette ore Citizine) and control (n=24, age of 45.3±2.4 years) without evidence of pharmacological resistance.

Results:
Patients were similar according to age, duration of current tobacco dependence, differing only in the quantity of cigarettes smoked per day (47±5,1 and 25.2±2,6, p<0.01). Ranked evaluation of the structure of the syndrome of pathological craving for tobacco smoking showed a predominance of the ideational component of maximum level (3,75±0,96 balls) in primary group, medium level (1,67±0,083 balls) – in the control group. The presence of patients with homozygotes for valine in the prime group was significantly higher than in the control (Χ2=5,78, p=0,0109). The same patterns identified for rs578776 polymorphism of the gene alpha3 subunit of the nicotinic cholinoreceptor. The results of the study of two haplotypes indicate their association with high intensity of Smoking and the lack of effect of application of standards of tobacco dependence therapy.

Conclusions:
Pre-clinical-genetic study of patients at the stage of selection of therapy will promote the formation of individualized approach to the treatment of patients with tobacco addiction.

Funding:
Supported by grant № 15-06-10839 of the Russian State Humanitarian Scientific Fund